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Microbiology
Doctoral Programme,
Faculty of Food and Biochemical Technology
The purpose of the study programme is to train specialists with a comprehensive understanding of microbial populations, their activity, phylogenetic and metabolic diversity, mechanisms controlling targeted changes of their genetic information or chemical principles affecting the relationship within microbial communities. The study programme is based on the combination of various forms of tuition and laboratory research, with the main emphasis on independence, initiative and critical approach of students. Alumni of this study programme should be able to routinely use any of the acquired knowledge, skills and competences for industrial or other applications. CareersAlumni of this study programme should have a comprehensive microbiological, biochemical and engineering background that will enable them to fully understand the microbial world. They will dispose of deep theoretical insight as well as practical skills in all key areas of microbiology, including biochemistry of microorganisms, molecular biology, genetic engineering and other closely related fields. The alumni of the study programme will find employment in all areas of biotechnology, food, pharmaceutical or chemical industry, in clinical laboratories, in the field of environmental sciences and agriculture. Last but not least, the alumni should be highly competent to work in academia. Programme Details
Vypsané disertační práce pro rok 2025/26Central Nervous System diagnostics
AnnotationCentral nervous system infections cause acute changes in mental and physical brain functions, leading to chronic impairment of cognitive, memory, and motor abilities. These changes are related to alterations in brain neuronal signaling in susceptible brain regions. This Ph.D. topic aims to utilize matrix-assisted laser desorption/ionization-mass spectrometry imaging and highly multiplex immunohistochemistry-based mass spectrometry imaging to analyze and quantify molecular interactions between host and pathogen in cases of neuroaspergillosis caused by Aspergillus fumigatus and pneumococcal meningitis caused by Streptococcus pneumoniae. The Ph.D. project will determine the optimal transport mechanism for microbial secondary metabolites, such as toxins and quorum sensing molecules, across the blood-brain barrier. The study will analyze the impact of microbial metabolites on neurotransmitter signaling, specifically through the dopaminergic and glutamatergic pathways, in critically affected brain regions. The candidate biomarkers will successfully diagnose CNS infections in human cerebrospinal fluid samples based on the host-pathogen molecular fingerprint.
Contact supervisor
Study place:
Institute of Microbiology of the CAS
Secondary metabolism of intracellular pathogens
AnnotationThe PhD candidate will study, correlate and mine the metabolism of intracellular pathogens within host cells. The candidate can solve five pressing diagnostic problems of our time, and together with the Stanford University, can address the dynamic range of analytical chemistry in mapping and quantifying intracellular pathogens in the host. Through this collaboration, the applicant will be able to work with isogenic strains, i.e., will always have host systems with very similar metabolomics and identical host genetic makeup. All directions of intracellular research are of the highest societal importance and involve the endemic fungus Coccidioides immitis, a Pf4 bacteriophage in the Gram-negative bacterium Pseudomonas aeruginosa, the AfPmV-1 polyomavirus in the filamentous fungus Aspergillus fumigatus, and the betaproteobacterium Mycetohabitans endofungorum, an intracellular symbiont of the filamentous fungus Rhizopus microsporus. Also a contribution to a novel diagnostic for Mycobacterium tubercullosis in mammalian cells is expected. The applicant will use the portfolio of infection metallomics, a set of dependent mass spectrometry, separation, and computational techniques.
Contact supervisor
Study place:
Institute of Microbiology of the CAS
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Updated: 25.3.2022 16:21, Author: Jan Kříž