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Biochemistry and Bioorganic Chemistry (double degree)
Doctoral Programme,
Faculty of Food and Biochemical Technology
Joint study programme with foreign universities - two diplomas for one study.
The aim of this programme is to prepare highly qualified professionals capable of independent scientific work, who will be involved in the implementation of new visions and methods in practice or will continue their scientific work at universities and scientific institutes and thus contribute to clarifying the functional principles of living organisms. The programme Biochemistry and Bioorganic Chemistry was created by merging two fields of chemistry. In this way, it will educate specialists preferentially oriented either to biochemistry or to bioorganic chemistry. The common denominator of both fields is to identify the chemical nature of important processes in living organisms, to study the relationship between the structure and biological activity of biopolymers, as well as natural organic compounds or their synthetic analogues. CareersGraduates of this programme are able to apply their knowledge in various fields such as biochemistry, cell biology and molecular genetics, microbiology, organic chemistry and chemistry of natural compounds (in relation to the dissertation topic). Based on the acquired knowledge, the student is able to plan the research project independently, critically assess the risks of the proposed procedures and apply innovative research methods. Another acquired competency of the graduate is the pedagogical and managerial experience due to involvment in teaching of bachelor and master programs, primarily in the role of assistants in laboratory courses and consultations of bachelor and master theses. Theoretical, experimental, pedagogical and managerial experience predispose the graduates to creative scientific and research activities, which is increasingly sought at various institutions of the institutes of the Academy of Sciences of the Czech Republic, universities, medical facilities, pharmaceutical companies and state and private research laboratories in the Czech Republic and abroad, dealing with problems in the field of biochemistry and bioorganic chemistry. Programme Details
Ph.D topics for previous study yearProduction of antibacterial peptides from marine organisms and evaluation of their biological activity
AnnotationDesign of bacterial expression system for production of existing antibacterial peptides identified in the laboratory of prof. Stensvåg at University in Tromso. Firstly, it is necessary to overcome the toxicity issues either by fusion with bulky protein or secretion achieved by fusion of the peptides to export sequence. Next step is upscale to massive production and purification for functional studies (pull down assay with bacterial cell lysate). Isolated products will be used for analysis of biological activity targeted against bacterial and yeast cells, including biofilms and determination of immunomodulatory effects. Subsequently it is planned a study of mechanisms leading to inhibition.
Contact supervisor
Study place:
Department of Biochemistry and Microbiology, FFBT, VŠCHT Praha
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Updated: 25.3.2022 16:21, Author: Jan Kříž