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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright UCT Prague 2017
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre
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[obsah] => Study programmes provided at the Faculty of Food and Biochemical Technology (FFBT) embrace both traditional fields of food science as well as current trends in the development of food and biochemical sciences. Traditional fields such as brewing, sugar manufacture, fermentation, and agrochemistry were taught at UCT Prague's historical predecessor, Prague Polytechnic, as early as the beginning of the last century.
Since the formation of the independent Institute of Chemical Technology, Prague (now University of Chemistry and Technology, Prague) in 1952, the Faculty has grown into an institution with a broad background in chemical, biochemical, engineering, and other disciplines, which illustrates the purposefulness of such a strong chemical-technological complex and the FFBT as its inseparable part—even on the international scale. The Faculty ranks among leading university centres of food science. In the course of its existence, the Faculty has turned out thousands of graduates who pursue their careers primarily in the food industry and related fields, in scientific research, and at schools and institutions of higher learning both in the Czech Republic and abroad.
The concentration of university teaching in all food-related fields—including applied biology and biochemistry—at FFBT represents one of the major strengths of the Faculty's existence within UCT Prague. However, besides advocates of the Faculty's existence within a chemistry university, naturally there are also many critics of such integration. Their major argument is that the food industry (the meat, dairy, and preservation industries in particular) as well as other fields are closely interrelated with farming production and should be taught at institutions focused on agriculture or veterinary science. Many agricultural and other universities and institutions of higher learning in the Czech Republic have lately introduced selected fields of food science in their study programmes, which will undoubtedly enhance desirable competition between their graduates.
The extent of this introduction to FFBT does not allow for a detailed description of the numerous diverse scientific projects implemented by the Faculty at present. We can only provide basic information to our future students and partner organizations about the scientific and research orientations of individual departments at the Faculty. All departments offer cooperation in scientific research and development; expertise and consulting; and continuing education for specialists and scientific workers in the form of various postgraduate programmes, short-term courses, and long-term scholarships. The Faculty's academic staff also prepare short-term specialized and retraining courses tailored to the needs of individual clients. Individual departments offer basic and specific analyses based on the most sophisticated methods and using state-of-the-art analytical apparatuses. The extent of consulting, expertise, and research and development activities is not restricted to the areas listed above, but it may be further expanded according to specific needs of industrial practice.
I believe that this introduction will provide basic information about the orientation of the Faculty and various forms of study offered by its individual departments, and that it will help us find new partners for cooperation in solving research and professional problems.
prof. Ing. Karel Melzoch, CSc
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Institute of Microbiology of the CAS
Degradation of bacterial signaling molecules by rational engineered Ntn-hydrolases as novel antibacterials
| Study place: | Institute of Microbiology of the CAS |
| Guaranteeing Departments: |
Department of Biotechnology
Institute of Microbiology of the CAS |
| Study Programme/Specialization: | Biotechnology ( in English language ) |
| Supervisor: | RNDr. Andrea Palyzová, Ph.D. |
| Expected Form of Study: | Full-time |
| Expected Method of Funding: | Scholarship |
Annotation
Growing antibiotic resistance will result globally in 10 million deaths annually by 2050. The targeted design of quorum-quenching (QQ) enzymes, negatively affecting the communication process in Gram-negative bacteria leading to biofilm formation, known as quorum sensing (QS) process, represents a clever strategy to effectively combat this threat. Construction and development of modified proteins from the Ntn-hydrolase group (e.g., ecPGA isolated from Escherichia coli) using genetic-molecular techniques (RF cloning, PCR-based methods, CRISPR/Cas technology) and biotechnological strategies (scale-up process, His tag purification) will lead to the develop of a unique QQ enzyme with properties for specific binding to a wider spectrum of HSL molecules (3-oxo-C12-HSL, C8-HSL, C6-HSL, C4-HSL). The designed modified enzymes will be used in in vitro interactions with selected HSL molecules, and their degradation activity will be monitored. Degradation efficiency will be tested in a biological model during biofilm development and maturation in significant HSL-dependent Gram-negative pathogens Pseudomonas aeruginosa, Klebsiella pneumoniae, and Aeromonas veronii. Biofilm morphology will be analyzed using electron microscopy, while the profile of signaling molecules synthesized in the bacterial population will be thoroughly examined using liquid chromatography with tandem mass spectrometry. The project will explore and enhance the biotechnological potential of these QQ enzymes to act as an alternative and complement to conventional antibiotic therapies and agents for medical and industrial applications in combating biofilm formation.
Changes in the urinary microbiome and metabolome in response to the therapeutic intervention in female patients with overactive bladder symptoms
| Study place: | Institute of Microbiology of the CAS |
| Guaranteeing Departments: |
Department of Biotechnology
Institute of Microbiology of the CAS |
| Study Programme/Specialization: | Biotechnology ( in English language ) |
| Supervisor: | RNDr. Andrea Palyzová, Ph.D. |
| Expected Form of Study: | Full-time |
| Expected Method of Funding: | Scholarship |
Annotation
Research into the microbiome of the urinary tract has progressed dramatically over the last decade. Currently, more than 500 bacterial species have been identified in urine, indicating significant diversity in the microbiome of the niche. As our understanding of the urinary microbiome grows, there is evidence of differences in microbiome composition between healthy individuals and those with lower urinary tract diseases. Overactive bladder (OAB) is a chronic disease of the lower urinary tract dysfunction affecting up to 20% of the population, more often women than men, characterized by sudden urges to urinate with a negative impact on quality of life. The pathophysiology of OAB is multifactorial, including metabolic syndrome, affective disorders, sex hormone deficiency, and other factors. The standard treatment of OAB is mainly based on lifestyle modification, behavioural therapy, and pharmacotherapy with anticholinergics. This study aims to correlate characteristics of the urinary microbiome and metabolome with OAB symptom severity and then to evaluate changes in the urinary microbiome and metabolome in response to therapeutic intervention for OAB. The study will include 210 subjects, approximately 60 with OAB symptoms and 150 healthy controls. Inclusion criteria for the OAB group will be the presence of clinical symptoms, the OAB-V8 patient-reported outcome questionnaire and the nerve growth factor (NGF) levels. Standard molecular techniques of DNA isolation and purification, PCR amplification, and sequencing by massively parallel sequencing on the Illumina MiSeq platform, complemented by bioinformatic analysis, will be used to gain insights into the microbiome. In addition to the composition of the microbial community, the molecular mechanisms at the level of identification of specific low molecular weight metabolites will play a key role in the patient´s condition. We will use non-targeted metabolomics to obtain comprehensive molecular profiles and semi-quantitatively determine the levels of unique metabolites. This will provide new insights into the biochemical functions of the detected metabolites associated with OAB and identify potential biomarkers associated with the development of this disease. ) ) [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) [api_suffix] => druh/I/jazyk/en/fakulta/22330/locale/en/ustav/319 )