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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright UCT Prague 2017
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre
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[obsah] => Study programmes provided at the Faculty of Food and Biochemical Technology (FFBT) embrace both traditional fields of food science as well as current trends in the development of food and biochemical sciences. Traditional fields such as brewing, sugar manufacture, fermentation, and agrochemistry were taught at UCT Prague's historical predecessor, Prague Polytechnic, as early as the beginning of the last century.
Since the formation of the independent Institute of Chemical Technology, Prague (now University of Chemistry and Technology, Prague) in 1952, the Faculty has grown into an institution with a broad background in chemical, biochemical, engineering, and other disciplines, which illustrates the purposefulness of such a strong chemical-technological complex and the FFBT as its inseparable part—even on the international scale. The Faculty ranks among leading university centres of food science. In the course of its existence, the Faculty has turned out thousands of graduates who pursue their careers primarily in the food industry and related fields, in scientific research, and at schools and institutions of higher learning both in the Czech Republic and abroad.
The concentration of university teaching in all food-related fields—including applied biology and biochemistry—at FFBT represents one of the major strengths of the Faculty's existence within UCT Prague. However, besides advocates of the Faculty's existence within a chemistry university, naturally there are also many critics of such integration. Their major argument is that the food industry (the meat, dairy, and preservation industries in particular) as well as other fields are closely interrelated with farming production and should be taught at institutions focused on agriculture or veterinary science. Many agricultural and other universities and institutions of higher learning in the Czech Republic have lately introduced selected fields of food science in their study programmes, which will undoubtedly enhance desirable competition between their graduates.
The extent of this introduction to FFBT does not allow for a detailed description of the numerous diverse scientific projects implemented by the Faculty at present. We can only provide basic information to our future students and partner organizations about the scientific and research orientations of individual departments at the Faculty. All departments offer cooperation in scientific research and development; expertise and consulting; and continuing education for specialists and scientific workers in the form of various postgraduate programmes, short-term courses, and long-term scholarships. The Faculty's academic staff also prepare short-term specialized and retraining courses tailored to the needs of individual clients. Individual departments offer basic and specific analyses based on the most sophisticated methods and using state-of-the-art analytical apparatuses. The extent of consulting, expertise, and research and development activities is not restricted to the areas listed above, but it may be further expanded according to specific needs of industrial practice.
I believe that this introduction will provide basic information about the orientation of the Faculty and various forms of study offered by its individual departments, and that it will help us find new partners for cooperation in solving research and professional problems.
prof. Ing. Karel Melzoch, CSc
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- Department of Biotechnology
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- Department of Saccharides and Cereals
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- Department of Food Analysis and Nutrition
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- Department of Chemistry of Natural Compounds
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Department of Biotechnology
Activation of biosynthetic pathways in actinomycetes for new bioactive metabolite discoveries
| Granting Departments: |
Institute of Microbiology of the CAS, v.v.i.
Department of Biotechnology |
| Study Programme/Specialization: | Biotechnology of Pharmaceuticals ( in English language ) |
| Supervisor: | prof. Ing. Jan Masák, CSc. |
Annotation
Actinomycetes, known for their production of bioactive metabolites such as antibiotics, anticancer agents, and immunosuppressants, were thought to be an exhausted resource due to the frequent rediscovery of known compounds. That this is not the case has been revealed through advanced sequencing techniques that have identified the potential of actinomycetes for new compounds at the genome level. The challenge is that many compound-producing biosynthetic pathways in actinomycetes are inactive under standard lab conditions. In this project, we will focus on our unique collection of actinomycetes from different parts of the world. Through genome sequencing of these strains, we have identified gene clusters encoding biosynthesis of metabolites with unusual structural motifs. Our goal is to employ modern methods to activate these pathways and characterize the produced compounds structurally and functionally. Optionally, we will focus on how the compounds are formed by studying key enzymes involved their biosynthesis. To accomplish this, we will employ a multidisciplinary approach that includes culturing bacteria, DNA editing, heterologous expression, bioinformatics, LC-MS with state-of-the-art instrumentation, and bioactivity testing against a panel of clinically relevant pathogens.
Biological activity of nanoparticles prepared by "green technologies"
| Granting Departments: | Department of Biotechnology |
| Study Programme/Specialization: | Biotechnology of Pharmaceuticals ( in English language ) |
| Supervisor: | prof. Ing. Alena Čejková, CSc. |
Annotation
The proven antimicrobial effects of metal nanoparticles as a result of their unique properties have ensured a rapid increase in commercial applications. Natural forms of nanoparticles are produced by many different biotic and abiotic mechanisms. Biotechnological approaches using microbial cells/lysates or plant tissues and extracts, among others, are currently of interest, especially given the fact that this approach allows modifications in the size and shape of the nanoparticles produced and provides opportunities for targeted surface modification (functionalization). An integral part of the work will be the characterization of the chemical and biochemical properties with emphasis on the biological activity of the prepared nanoparticles.
Evaluation of the effect of secondary metabolites of <i>Monascus</i> fungus on gram-positive spore-forming bacteria
| Granting Departments: | Department of Biotechnology |
| Study Programme/Specialization: | Biotechnology ( in English language ) |
| Supervisor: | prof. Dr. Ing. Petra Patáková |
Annotation
The essence of the work will be to collect different types of secondary metabolites, especially pigments, formed by different fungi of the genus Monascus, in the form of both complex extracts and pure substances and to test their effect on Gram-positive sporulating bacteria, especially the genera Clostridium and Bacillus. Bacteria of these species are common food contaminants and their complete eradication is difficult due to the formation of highly resistant spores. Both staining and antimicrobial effects have been demonstrated for Monascus pigments, but testing of the antimicrobial effect has been limited to vegetative cells. Inhibition of sporulation and suppression of spore germination will also be tested in this work. Advanced methods such as flow cytometry together with fluorescent cell labelling, RT-qPCR and transcriptomic analysis will be used.
Nanocomposites with high activity against pathogenic microorganisms
| Granting Departments: | Department of Biotechnology |
| Study Programme/Specialization: | Biotechnology of Pharmaceuticals ( in English language ) |
| Supervisor: | prof. Ing. Jan Masák, CSc. |
Annotation
Nanoparticles and other nanostructures often have high biological activity. In this case, the biological activity is the result of a set of characteristic properties of these structures, such as their shape and size and their chemical composition. Initially, the predominant study of the biological activities of nanoparticles of metals and their oxides is shifting towards composite nanoparticles consisting of, for example, various polymers and metals. The spatial arrangement of these composites is often crucial. The topic of this dissertation is to find suitable procedures, with emphasis on "green synthesis", for the preparation of nanocomposites based on natural polymers such as chitosan and lignin in combination with various metals. The aim will be to obtain nanostructures with high antimicrobial activity, which are particularly useful in medicine and related fields.
Institute of Chemical Process Fundamentals of the CAS, v.v.i.
Phycocyanin production in autotrophic, heterotrophic and mixotrophic modes of microalgae cultivation
| Granting Departments: |
Department of Biotechnology
Institute of Chemical Process Fundamentals of the CAS, v.v.i. |
| Study Programme/Specialization: | Biotechnology ( in English language ) |
| Supervisor: | Ing. Irena Brányiková, Ph.D. |
Annotation
Phycocyanin (PC) is a blue-coloured protein pigment associated with the accessory light-harvesting complex in microalgae. It is a water-soluble, multimeric compound having fluorescent tetrapyrrole chromophores. Recently, PC has been reported to have various therapeutic properties such as antioxidant, antidiabetic, antiaging, hepatoprotective, antimicrobial, anticancerous, immunoregulating, and antiinflammatory. Althought PC is already used in food technology and cosmetics, its potential is not yet fully exploited especially due to rapid degradation at acidic pH and relatively high price. The aim of this work will be to cultivate the cyanobacteria Limnospira sp., Aphanizomenon flos-aquae and red alga Galdieria sulphuraria (i), to determine the productivity of biomass and PC under different conditions in the autotrophic, heterotrophic and mixotrophic regime (ii), to optimize the production conditions on a laboratory scale (e.g. temperature, pH, source of nitrogen, carbon and energy) (iii), assess the chemical and thermal stability of PC (iv) and evaluate methods of PC extraction from the biomass including production costs estimation.
Institute of Microbiology of the CAS, v.v.i.
Activation of biosynthetic pathways in actinomycetes for new bioactive metabolite discoveries
| Granting Departments: |
Department of Biotechnology
Institute of Microbiology of the CAS, v.v.i. |
| Study Programme/Specialization: | Biotechnology ( in English language ) |
| Supervisor: | prof. Ing. Jan Masák, CSc. |
Annotation
Actinomycetes, known for their production of bioactive metabolites such as antibiotics, anticancer agents, and immunosuppressants, were thought to be an exhausted resource due to the frequent rediscovery of known compounds. That this is not the case has been revealed through advanced sequencing techniques that have identified the potential of actinomycetes for new compounds at the genome level. The challenge is that many compound-producing biosynthetic pathways in actinomycetes are inactive under standard lab conditions. In this project, we will focus on our unique collection of actinomycetes from different parts of the world. Through genome sequencing of these strains, we have identified gene clusters encoding biosynthesis of metabolites with unusual structural motifs. Our goal is to employ modern methods to activate these pathways and characterize the produced compounds structurally and functionally. Optionally, we will focus on how the compounds are formed by studying key enzymes involved their biosynthesis. To accomplish this, we will employ a multidisciplinary approach that includes culturing bacteria, DNA editing, heterologous expression, bioinformatics, LC-MS with state-of-the-art instrumentation, and bioactivity testing against a panel of clinically relevant pathogens.